SEA-AD - Multiregion single nucleus transcriptomes

SEA-AD - Multiregion single nucleus transcriptomes#

SEA-AD - Multiregion is derived from a single nuclei transcriptomic dataset containing 8,641,342 nuclei from 84 donors. This includes gene expression data from both snRNA-seq and Multi-ome data sets. ATAC-seq information from the Multiome cells and additional nuclei collected from snATAC-seq are available at SEA-AD.org.

All associated metadata is publicly available as an AWS Public Dataset hosted on Amazon S3 and through the Allen Brain Cell Atlas Access (abc_atlas_access) package.

The expression matrices and associated metadata are hosted on AWS S3 bucket as a AWS Public Dataset:

Component

Current Version

Size

Expression Matrices

s3://allen-brain-cell-atlas/expression_matrices/SEA-AD-Multiregion-10X/20260630/

144.2 GB

Cell and gene metadata

s3://allen-brain-cell-atlas/metadata/SEA-AD-Multiregion-10X/20260711/

2.0 GB

Data is being shared under the CC BY NC 4.0 license.

Related resources:

  • Taxonomy derived from from the the SEA-AD Multiregion datasetCaudate Nucleus (SEA-AD-Multiregion-taxonomy)

  • Taxonomy derived from from the Caudate Nucleus, reusing Supertypes and Groups from the SEA-AD-Multiregion and the HMBA-BG taxonomies (SEA-AD-CaH-taxonomy)

  • Approximately 800 thousand single nuclei from the Human Caudate. (SEA-AD-CaH-10X)

Associated notebooks: